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Clinicians can use a combination of estimated glomerular filtration rate  eGFR , proteinuria, and type of chronic kidney disease to estimate stanley cup  how soon children will progress to end-stage renal disease  ESRD , according to new study findings published i stanley cup n the American Journal of Kidney Diseases.Susan L. Furth, MD, of Childrenrsquo  Hospital in Philadelphia, and her colleagues examined 2 cohorts of children to determine criteria for pediatric progression to renal replacement therapy, 50% reduction in eGFR, or eGFR less than 15 mL/min/1.73 m2. The team analyzed data from 1232 children aged 1 to 18 years from the North American CKiD  Chronic Kidney Disease in Children  study and the European ESCAPE  Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients  trial.Based on models, the investigators defined ESRD risk categories by eGFR stage  60ndash;89, 45ndash;59, 30ndash;44, and 15ndash;29 mL/min/1.73 m2  and urinary protein to creatinine ratio  UPCR   less than 0.5, 0.5ndash;2.0, and more than 2.0 mg/mg . According to the staging system, a child with eGFR of 45 to 90 mL/min/1.73 m2 and UPCR less than 0.5 mg/mg woul stanley mugs d progress to ESRD in 10 or more years. A child with an eGFR of 15 to 30 mL/min/1.73 m2 and UPCR more than 2 mg/mg would progress to ESRD in 0.8 years. Children with glomerular disease would decline almost twice as fast as those with non-glomerular disease.The staging system is more informative than eGFR alone, the Unau Lupus Nephritis Remission Predicts Good Pregnancy Outcomes
HANOVER 鈥?Dartmouth College has secured an easement from a landowner near Rennie Farm to treat contaminated groundwater that has migrated from the former college l stanley canada aboratory dump site, a step the college says will expedite the overall cleanup. Dartmouth is working to obtain state and local permits to install wells that will extract groundwater and pump it underneath Rennie Road to its existing treatment system at the form stanley cup er dump site, college officials said on Thursday.The 15-year easement is intended to help accelerate the cleanup of the spread of the chemical 1,4 dioxane, which was found in soil and groundwater both on Rennie Farm and on private property across Rennie Road.The rural site had been used as a dumping ground in the 1960s and 1970s for the carcasses of test animals used at what was then known as Dartmouth Medical School. Dartmouth excavated most of the waste in 2011, but dioxane was later found in a private well along Rennie Road.Ellen Arnold, the Dartmouth lawyer who has been helping to oversee the cleanup, said the work will help speed up the removal of dioxane from the area. Weve had excellent results from the existing system. There has been no expansion of the contamination,  she said.Jim Wieck, a consultant with GZA Geo Environmental Inc., the contractor that is handling the cleanup, said state officials had not req stanley mug uired Dartmouth to expand the cleanup.Join your neighbors and subscribe!Award-winning coverage on breaking news and todays top stories in and aro

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